GAB2 Alleles Modify Alzheimer's Risk in APOE ɛ4 Carriers

Eric M. Reiman,* Jennifer A. Webster, Amanda J. Myers, John Hardy, Travis Dunckley, Victoria L. Zismann, Keta D. Joshipura, John V. Pearson, Diane Hu-Lince, Matthew J. Huentelman, David W. Craig, Keith D. Coon, Winnie S. Liang, RiLee H. Herbert, Thomas Beach, Kristen C. Rohrer, Alice S. Zhao, Doris Leung, Leslie Bryden, Lauren Marlowe, Mona Kaleem, Diego Mastroeni, Andrew Grover, Christopher B. Heward, Rivka Ravid, Joseph Rogers, Michael L. Hutton, Stacey Melquist, Ron C. Petersen, Gene E. Alexander, Richard J. Caselli, Walter Kukull, Andreas Papassotiropoulos, and Dietrich A. Stephan* Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA Banner Alzheimer’s Institute, Phoenix, AZ 85006, USA Department of Psychiatry, University of Arizona, Tucson, AZ 85724, USA Department of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL 33136, USA Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, 20892, USA Reta Lila Weston Laboratories, Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N, 3BG, England Division of Thoracic Oncology Research, St. Joseph’s Hospital, Phoenix, AZ 85013, USA Sun Health Research Institute, Sun City, AZ 85351, USA Kronos Science Laboratory, Phoenix, AZ 85016, USA Netherlands Institute for Neurosciences, Dutch Royal Academy of Arts and Sciences, Meibergdreef 47 AB Amsterdam, The Netherlands Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA Department of Psychology, Arizona State University, Tempe, AZ 85281, USA Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA Division of Molecular Psychology and Life Sciences Training Facility, Biozentrum, University of Basel, Switzerland National Alzheimer’s Coordinating Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA Arizona Alzheimer’s Consortium, Phoenix AZ 85006, USA These authors contributed equally to this work. *Correspondence: [email protected] (E.M.R.), [email protected] (D.A.S.) DOI 10.1016/j.neuron.2007.05.022